› 7ciq

X-ray diffraction
1.59Å resolution

Phosphorylation modification of MHC I polypeptide

Released:
DOI: 10.2210/pdb7ciq/pdb
PDB entry 7ciq coloured by chain, front view.
PDB entry 7ciq coloured by chain, side view.
PDB entry 7ciq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules.
Zhao Y, Sun M, Zhang N, Liu X, Yue C, Feng L, Ji S, Liu X, Qi J, Wong CCL, Gao GF, Liu WJ
OpenAccess logo iScience 25 104013 (2022)
PMID: 35310951

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-131274 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O78189 (Residues: 25-300; Coverage: 82%)
Gene name: HLA-B
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Protein SON Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 1.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18583 (Residues: 2026-2035; Coverage: 0%)
Gene names: C21orf50, DBP5, HSPC310, HSPC312, KIAA1019, NREBP, SON

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21
Unit cell:
a: 43.402Å b: 52.352Å c: 93.205Å
α: 90° β: 93.228° γ: 90°
R-values:
R R work R free
0.174 0.172 0.209
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 citation in other articles

APE-Gen2.0: Expanding Rapid Class I Peptide-Major Histocompatibility Complex Modeling to Post-Translational Modifications and Noncanonical Peptide Geometries.
Fasoulis et al. (2024)
1 more

1 mention without citation

Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules.
Zhao et al. (2022)