› 7dhz

X-ray diffraction
1.74Å resolution

Arsenic-bound p53 DNA-binding domain mutant R249S

Released:
DOI: 10.2210/pdb7dhz/pdb
PDB entry 7dhz coloured by chain, front view.
PDB entry 7dhz coloured by chain, side view.
PDB entry 7dhz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Chen S, Wu JL, Liang Y, Tang YG, Song HX, Wu LL, Xing YF, Yan N, Li YT, Wang ZY, Xiao SJ, Lu X, Chen SJ, Lu M
Cancer Cell 39 225-239.e8 (2021)
PMID: 33357454

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chains: A, B
Molecule details ›
Chains: A, B
Length: 200 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-293; Coverage: 51%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain

Ligands and Environments

3 bound ligands:
Ligand GOL 3 x GOL
Ligand ARS 2 x ARS
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21
Unit cell:
a: 41.551Å b: 68.768Å c: 66.784Å
α: 90° β: 93.22° γ: 90°
R-values:
R R work R free
0.2 0.197 0.256
Expression system: Escherichia coli

Quick links

Citations

32 review citations

Evolving therapeutic landscape of advanced hepatocellular carcinoma.
Yang et al. (2023)
31 more

6 mentions without citation

p53 and Zinc: A Malleable Relationship.
Ha et al. (2022)
5 more