› 7dtv

Electron Microscopy
3.5Å resolution

Human Calcium-Sensing Receptor bound with L-Trp and calcium ions

Released:
DOI: 10.2210/pdb7dtv/pdb
PDB entry 7dtv coloured by chain, front view.
PDB entry 7dtv coloured by chain, side view.
PDB entry 7dtv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan.
Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D, Liu L, Tian C
OpenAccess logo Cell Res 31 383-394 (2021)
PMID: 33603117
Related structures: EMD-30855

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Extracellular calcium-sensing receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 1099 amino acids
Theoretical weight: 123.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41180 (Residues: 20-1078; Coverage: 100%)
Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand TRP 2 x TRP
Ligand CA 4 x CA
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-30855
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Extracellular Calcium Receptor as a Target for Glutathione and Its Derivatives.
Goralski et al. (2022)
1 more

4 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
3 more