› 7e3w

X-ray diffraction
1.55Å resolution

Metallo beta-lactamase fold protein (cAMP bound)

Released:
DOI: 10.2210/pdb7e3w/pdb
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PDB entry 7e3w coloured by chain, front view.
PDB entry 7e3w coloured by chain, side view.
PDB entry 7e3w coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structural and functional studies of SAV1707 from Staphylococcus aureus elucidate its distinct metal-dependent activity and a crucial residue for catalysis.
Kim DG, Lee KY, Lee SJ, Cheon SH, Choi Y, Lee HH, Ahn HC, Lee BJ
Acta Crystallogr D Struct Biol 77 587-598 (2021)
PMID: 33950015

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173453 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UPF0173 metal-dependent hydrolase SAOUHSC_01815 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 246 amino acids
Theoretical weight: 27.22 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FXM0 (Residues: 1-229; Coverage: 100%)
Gene name: SAOUHSC_01815
Sequence domains: Beta-lactamase superfamily domain

Ligands and Environments

5 bound ligands:
Ligand CMP 6 x CMP
Ligand TRS 2 x TRS
Ligand CL 2 x CL
Ligand ZN 12 x ZN
Ligand NI 12 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P212121
Unit cell:
a: 70.729Å b: 121.503Å c: 187.251Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.228
Expression system: Escherichia coli

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