› 7e59

X-ray diffraction
3Å resolution

interferon-inducible anti-viral protein truncated

Released:
DOI: 10.2210/pdb7e59/pdb
PDB entry 7e59 coloured by chain, front view.
PDB entry 7e59 coloured by chain, side view.
PDB entry 7e59 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, Li N, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D, Wang Z, Kirchhoff F, Yang H
Proc Natl Acad Sci U S A 118 (2021)
PMID: 33876762

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-572524 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate-binding protein 5 Chains: A, B, C, G
Molecule details ›
Chains: A, B, C, G
Length: 487 amino acids
Theoretical weight: 54.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96PP8 (Residues: 1-486; Coverage: 83%)
Gene names: GBP5, UNQ2427/PRO4987
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Unit cell:
a: 90.874Å b: 137.312Å c: 203.308Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.259
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Functional cross-species conservation of guanylate-binding proteins in innate immunity.
Schelle et al. (2023)
2 more