› 7ekt

Electron Microscopy
3.02Å resolution

human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596

Released:
DOI: 10.2210/pdb7ekt/pdb
PDB entry 7ekt coloured by chain, front view.
PDB entry 7ekt coloured by chain, side view.
PDB entry 7ekt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of human α7 nicotinic acetylcholine receptor activation.
Zhao Y, Liu S, Zhou Y, Zhang M, Chen H, Eric Xu H, Sun D, Liu L, Tian C
OpenAccess logo Cell Res 31 713-716 (2021)
PMID: 33958730
Related structures: EMD-31176

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153193 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neuronal acetylcholine receptor subunit alpha-7 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 502 amino acids
Theoretical weight: 56.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P36544 (Residues: 1-502; Coverage: 100%)
Gene names: CHRNA7, NACHRA7
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 5 x NAG
Ligand CLR 5 x CLR
Ligand I33 5 x I33
Ligand I34 5 x I34
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.02Å
Relevant EMDB volumes: EMD-31176
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications.
Kasheverov et al. (2022)
4 more

5 mentions without citation

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators.
Manetti et al. (2023)
4 more