› 7eor

Electron Microscopy
4Å resolution

Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901 bound state

Released:
DOI: 10.2210/pdb7eor/pdb
PDB entry 7eor coloured by chain, front view.
PDB entry 7eor coloured by chain, side view.
PDB entry 7eor coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors.
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S
Neuron 109 2443-2456.e5 (2021)
PMID: 34186027
Related structures: EMD-31228

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170224 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 2A Chains: A, C
Molecule details ›
Chains: A, C
Length: 853 amino acids
Theoretical weight: 95.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12879 (Residues: 1-842; Coverage: 57%)
Gene names: GRIN2A, NMDAR2A
Sequence domains:
Glutamate receptor ionotropic, NMDA 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 847 amino acids
Theoretical weight: 95.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 14 x NAG
Ligand 6RM 2 x 6RM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-31228
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
1 more

1 mention without citation

Structural insights into NMDA receptor pharmacology.
Zhou et al. (2023)