› 7f6g

Electron Microscopy
2.9Å resolution

Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII

Released:
DOI: 10.2210/pdb7f6g/pdb
PDB entry 7f6g coloured by chain, front view.
PDB entry 7f6g coloured by chain, side view.
PDB entry 7f6g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.
Zhang D, Liu Y, Zaidi SA, Xu L, Zhan Y, Chen A, Guo J, Huang XP, Roth BL, Katritch V, Cherezov V, Zhang H
EMBO J 42 e112940 (2023)
PMID: 37038975
Related structures: EMD-31479

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-156134 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Angiotensin receptor AT1R Chain: A
Molecule details ›
Chain: A
Length: 725 amino acids
Theoretical weight: 81.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
SAR1-AngII Chain: L
Molecule details ›
Chain: L
Length: 8 amino acids
Theoretical weight: 1 KDa
Source organism: Homo sapiens
Expression system: Not provided
Guanine nucleotide-binding protein G(q) subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 369 amino acids
Theoretical weight: 43.53 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: C
Molecule details ›
Chain: C
Length: 354 amino acids
Theoretical weight: 39.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: D
Molecule details ›
Chain: D
Length: 81 amino acids
Theoretical weight: 9.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand CLR 6 x CLR
1 modified residue:
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-31479
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

3 review citations

Advances in the allostery of angiotensin II type 1 receptor.
Zhang et al. (2023)
2 more

4 mentions without citation

Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Peng et al. (2023)
3 more