› 7fap

Electron Microscopy
3.4Å resolution

Structure of VAR2CSA-CSA 3D7

Released:
DOI: 10.2210/pdb7fap/pdb
PDB entry 7fap coloured by chain, front view.
PDB entry 7fap coloured by chain, side view.
PDB entry 7fap coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum.
Wang W, Wang Z, Yang X, Gao Y, Zhang X, Cao L, Dai A, Sun J, Sun L, Jiang L, Chen Z, Wang L
OpenAccess logo Cell Discov 7 94 (2021)
PMID: 34663782
Related structures: EMD-31504

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Erythrocyte membrane protein 1, PfEMP1 Chain: A
Molecule details ›
Chain: A
Length: 2630 amino acids
Theoretical weight: 306.19 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8I639 (Residues: 1-2630; Coverage: 86%)
Gene name: PF3D7_1200600
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: BDP, ASG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-31504
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties.
Zheng et al. (2023)
8 other articles