› 7jna

Electron Microscopy
3.6Å resolution

Cryo-EM structure of human proton-activated chloride channel PAC at pH 8

Released:
DOI: 10.2210/pdb7jna/pdb
PDB entry 7jna coloured by chain, front view.
PDB entry 7jna coloured by chain, side view.
PDB entry 7jna coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and pH-sensing mechanism of the proton-activated chloride channel.
Ruan Z, Osei-Owusu J, Du J, Qiu Z, Lü W
OpenAccess logo Nature 588 350-354 (2020)
PMID: 33149300
Related structures: EMD-22403

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Proton-activated chloride channel Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 350 amino acids
Theoretical weight: 40.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H813 (Residues: 1-350; Coverage: 100%)
Gene names: C1orf75, PACC1, TMEM206
Sequence domains: TMEM206 protein family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-22403
Expression system: Homo sapiens

Quick links

Citations

3 review citations

From Pinocytosis to Methuosis-Fluid Consumption as a Risk Factor for Cell Death.
Ritter et al. (2021)
2 more

7 mentions without citation

Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 2: Functional and Molecular Properties of ASOR/PAC Channels and Their Roles in Cell Volume Dysregulation and Acidotoxic Cell Death.
Okada et al. (2021)
6 more