7jv8

X-ray diffraction
2.46Å resolution

Function and Biology Details

Reactions catalysed:
Thymidylate + H(2)O = thymidine + phosphate
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
A 2'-deoxyribonucleoside 5'-monophosphate + H(2)O = a 2'-deoxyribonucleoside + phosphate
CMP + H(2)O = cytidine + phosphate
IMP + H(2)O = inosine + phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-539835 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'-nucleotidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 529 amino acids
Theoretical weight: 58.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21589 (Residues: 27-549; Coverage: 95%)
Gene names: NT5, NT5E, NTE
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 87.876Å b: 102.354Å c: 129.609Å
α: 90° β: 103.22° γ: 90°
R-values:
R R work R free
0.221 0.22 0.279
Expression system: Homo sapiens