› 7kj1

X-ray diffraction
2.15Å resolution

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-2 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 197 amino acids
Theoretical weight: 21.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32119 (Residues: 2-198; Coverage: 100%)
Gene names: NKEFB, PRDX2, TDPX1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 233.2Å b: 88.3Å c: 125.2Å
α: 90° β: 99.2° γ: 90°
R-values:
R R work R free
0.197 0.195 0.236
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Antioxidant Therapy in Cancer: Rationale and Progress.
Luo et al. (2022)
2 more

1 mention without citation

Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.
Peskin et al. (2021)