› 7l66

X-ray diffraction
1.75Å resolution

C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Methyl-GlcNAc

Released:
DOI: 10.2210/pdb7l66/pdb
PDB entry 7l66 coloured by chain, front view.
PDB entry 7l66 coloured by chain, side view.
PDB entry 7l66 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
Feinberg H, Jégouzo SAF, Lasanajak Y, Smith DF, Drickamer K, Weis WI, Taylor ME
OpenAccess logo J Biol Chem 296 100368
PMID: 33545173

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage mannose receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22897 (Residues: 646-779; Coverage: 9%)
Gene names: CLEC13D, CLEC13DL, MRC1, MRC1L1
Sequence domains: Lectin C-type domain

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand 2F8 1 x 2F8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: P21212
Unit cell:
a: 54.484Å b: 66.633Å c: 34.436Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases.
He et al. (2022)
8 more

3 mentions without citation

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
Feinberg et al. (2021)
2 more