› 7lga

X-ray diffraction
1.9Å resolution

PEG10 CA-like C-terminal domain

Released:
DOI: 10.2210/pdb7lga/pdb
PDB entry 7lga coloured by chain, front view.
PDB entry 7lga coloured by chain, side view.
PDB entry 7lga coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins.
Zurowska K, Alam A, Ganser-Pornillos BK, Pornillos O
Proteins 90 309-313 (2022)
PMID: 34357660

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-567259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retrotransposon-derived protein PEG10 Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 101 amino acids
Theoretical weight: 11.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86TG7 (Residues: 161-238; Coverage: 11%)
Gene names: EDR, KIAA1051e, MAR2, MART2, MEF3L1, PEG10, RGAG3

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 51.598Å b: 70.289Å c: 52.689Å
α: 90° β: 98.102° γ: 90°
R-values:
R R work R free
0.184 0.182 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The human retroviral-like aspartic protease 1 (ASPRV1): From in vitro studies to clinical correlations.
Mótyán et al. (2024)

4 mentions without citation

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.
Black et al. (2023)
3 more