› 7m5y

Electron Microscopy
3Å resolution

human ATP13A2 in the outward-facing E2 state bound to spermine and magnesium fluoride

Released:
DOI: 10.2210/pdb7m5y/pdb
PDB entry 7m5y coloured by chain, front view.
PDB entry 7m5y coloured by chain, side view.
PDB entry 7m5y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Tillinghast J, Drury S, Bowser D, Benn A, Lee KPK
Mol Cell 81 4650-4662.e4 (2021)
PMID: 34715014
Related structures: EMD-23685

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyamine-transporting ATPase 13A2 Chain: A
Molecule details ›
Chain: A
Length: 1189 amino acids
Theoretical weight: 129.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NQ11 (Residues: 1-1180; Coverage: 100%)
Gene names: ATP13A2, PARK9
Sequence domains:

Ligands and Environments

11 bound ligands:
Ligand MG 1 x MG
Ligand MF4 1 x MF4
Ligand Y01 3 x Y01
Ligand LMT 1 x LMT
Ligand CLR 4 x CLR
Ligand D10 9 x D10
Ligand C14 1 x C14
Ligand D12 1 x D12
Ligand NAG 1 x NAG
Ligand SPK 1 x SPK
Ligand EUJ 1 x EUJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-23685
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Polyamines in cancer: integrating organismal metabolism and antitumour immunity.
Holbert et al. (2022)
4 more