› 7mp3

X-ray diffraction
2.55Å resolution

Grb7-SH2 domain in complex with bicyclic peptide B8

Released:
DOI: 10.2210/pdb7mp3/pdb
PDB entry 7mp3 coloured by chain, front view.
PDB entry 7mp3 coloured by chain, side view.
PDB entry 7mp3 coloured by chain, top view.
Source organisms:
Primary publication:
Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability.
Sturre NP, Colson RN, Shah N, Watson GM, Yang X, Wilce MCJ, Price JT, Wilce JA
OpenAccess logo Biomedicines 10 (2022)
PMID: 35625882

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-553641 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 120 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
bicyclic peptide B8 Chains: L, N
Molecule details ›
Chains: L, N
Length: 11 amino acids
Theoretical weight: 1.41 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 42.156Å b: 53.122Å c: 54.809Å
α: 103.983° β: 101.997° γ: 100.048°
R-values:
R R work R free
0.223 0.221 0.264
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Peptide therapeutics in the management of metastatic cancers.
Bose et al. (2022)
1 other article

1 mention without citation

Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability.
Sturre et al. (2022)