PDB 7mqa structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA

ATP + H(2)O = ADP + phosphate

Biochemical function:

RNA binding

Biological process:

ribosomal small subunit biogenesis

Cellular component:

small-subunit processome

Sequence domains:

187 more domains

Structure analysis Details

Assembly composition:

hetero 72-mer (preferred)

PDBe Complex ID:

PDB-CPX-517369 (preferred)

Entry contents:

65 distinct polypeptide molecules
3 distinct RNA molecules

Macromolecules (68 distinct):

40S ribosomal protein S18 Chain: L3

Molecule details ›

Chain: L3
Length: 116 amino acids
Theoretical weight: 12.67 KDa
Source organism: Homo sapiens

Small ribosomal subunit protein eS4, X isoform Chain: L4

Molecule details ›

Chain: L4
Length: 263 amino acids
Theoretical weight: 29.65 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62701 (Residues: 1-263; Coverage: 100%)

Sequence domains:

Small ribosomal subunit protein uS7 Chain: L5

Molecule details ›

Chain: L5
Length: 204 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P46782 (Residues: 1-204; Coverage: 100%)

Sequence domains: Ribosomal protein S7p/S5e

Small ribosomal subunit protein eS6 Chain: L6

Molecule details ›

Chain: L6
Length: 249 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62753 (Residues: 1-249; Coverage: 100%)

Sequence domains: Ribosomal protein S6e

Small ribosomal subunit protein eS7 Chain: L7

Molecule details ›

Chain: L7
Length: 194 amino acids
Theoretical weight: 22.17 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62081 (Residues: 1-194; Coverage: 100%)

Sequence domains: Ribosomal protein S7e

Small ribosomal subunit protein eS8 Chain: L8

Molecule details ›

Chain: L8
Length: 208 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62241 (Residues: 1-208; Coverage: 100%)

Sequence domains: Ribosomal protein S8e

Small ribosomal subunit protein uS4 Chain: L9

Molecule details ›

Chain: L9
Length: 194 amino acids
Theoretical weight: 22.64 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P46781 (Residues: 1-194; Coverage: 100%)

Sequence domains:

Small ribosomal subunit protein eS12 Chain: LA

Molecule details ›

Chain: LA
Length: 132 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P25398 (Residues: 1-132; Coverage: 100%)

Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Small ribosomal subunit protein uS9 Chain: LC

Molecule details ›

Chain: LC
Length: 146 amino acids
Theoretical weight: 16.48 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62249 (Residues: 1-146; Coverage: 100%)

Sequence domains: Ribosomal protein S9/S16

Small ribosomal subunit protein uS17 Chain: LD

Molecule details ›

Chain: LD
Length: 158 amino acids
Theoretical weight: 18.47 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62280 (Residues: 1-158; Coverage: 100%)

Sequence domains:

Small ribosomal subunit protein eS24 Chain: LF

Molecule details ›

Chain: LF
Length: 133 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62847 (Residues: 1-133; Coverage: 100%)

Sequence domains: Ribosomal protein S24e

Small ribosomal subunit protein eS28 Chain: LG

Molecule details ›

Chain: LG
Length: 69 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62857 (Residues: 1-69; Coverage: 100%)

Sequence domains: Ribosomal protein S28e

WD repeat-containing protein 75 Chain: LH

Molecule details ›

Chain: LH
Length: 830 amino acids
Theoretical weight: 94.61 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q8IWA0 (Residues: 1-830; Coverage: 100%)

Sequence domains: WD domain, G-beta repeat

Nucleolar protein 11 Chain: LI

Molecule details ›

Chain: LI
Length: 678 amino acids
Theoretical weight: 73.44 KDa
Source organism: Homo sapiens

U3 small nucleolar RNA-associated protein 15 homolog Chain: LJ

Molecule details ›

Chain: LJ
Length: 518 amino acids
Theoretical weight: 58.5 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q8TED0 (Residues: 1-518; Coverage: 100%)

Sequence domains:

WD repeat-containing protein 43 Chains: LK, LL

Molecule details ›

Chains: LK, LL
Length: 677 amino acids
Theoretical weight: 74.99 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q15061 (Residues: 1-677; Coverage: 100%)

Sequence domains:

HEAT repeat-containing protein 1 Chain: LM

Molecule details ›

Chain: LM
Length: 2144 amino acids
Theoretical weight: 242.65 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9H583 (Residues: 1-2144; Coverage: 100%)

Sequence domains:

U3 small nucleolar RNA-associated protein 4 homolog Chain: LN

Molecule details ›

Chain: LN
Length: 686 amino acids
Theoretical weight: 76.99 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q969X6 (Residues: 1-686; Coverage: 100%)

Sequence domains: WD domain, G-beta repeat

Periodic tryptophan protein 2 homolog Chain: LO

Molecule details ›

Chain: LO
Length: 919 amino acids
Theoretical weight: 102.57 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q15269 (Residues: 1-919; Coverage: 100%)

Sequence domains:

U3 small nucleolar RNA-associated protein 6 homolog Chain: LP

Molecule details ›

Chain: LP
Length: 597 amino acids
Theoretical weight: 70.3 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9NYH9 (Residues: 1-597; Coverage: 100%)

Sequence domains: U3 small nucleolar RNA-associated protein 6

WD repeat-containing protein 3 Chain: LQ

Molecule details ›

Chain: LQ
Length: 943 amino acids
Theoretical weight: 106.25 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9UNX4 (Residues: 1-943; Coverage: 100%)

Sequence domains:

Transducin beta-like protein 3 Chain: LR

Molecule details ›

Chain: LR
Length: 808 amino acids
Theoretical weight: 89.14 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q12788 (Residues: 1-808; Coverage: 100%)

Sequence domains:

U3 small nucleolar RNA-associated protein 18 homolog Chain: LS

Molecule details ›

Chain: LS
Length: 556 amino acids
Theoretical weight: 62.1 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y5J1 (Residues: 1-556; Coverage: 100%)

Sequence domains: WD domain, G-beta repeat

WD repeat-containing protein 36 Chain: LT

Molecule details ›

Chain: LT
Length: 951 amino acids
Theoretical weight: 105.44 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q8NI36 (Residues: 1-951; Coverage: 100%)

Sequence domains:

DDB1- and CUL4-associated factor 13 Chain: LU

Molecule details ›

Chain: LU
Length: 445 amino acids
Theoretical weight: 51.49 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9NV06 (Residues: 1-445; Coverage: 100%)

Sequence domains:

WD repeat-containing protein 46 Chain: LW

Molecule details ›

Chain: LW
Length: 610 amino acids
Theoretical weight: 68.19 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O15213 (Residues: 1-610; Coverage: 100%)

Sequence domains:

Active regulator of SIRT1 Chain: LY

Molecule details ›

Chain: LY
Length: 136 amino acids
Theoretical weight: 15.47 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q86WX3 (Residues: 1-136; Coverage: 100%)

Sequence domains: Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1

U3 small nucleolar ribonucleoprotein protein IMP3 Chain: LZ

Molecule details ›

Chain: LZ
Length: 184 amino acids
Theoretical weight: 21.89 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9NV31 (Residues: 1-184; Coverage: 100%)

Sequence domains:

U3 small nucleolar ribonucleoprotein protein MPP10 Chain: NA

Molecule details ›

Chain: NA
Length: 681 amino acids
Theoretical weight: 78.99 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O00566 (Residues: 1-681; Coverage: 100%)

Sequence domains: Mpp10 protein

Something about silencing protein 10 Chain: NB

Molecule details ›

Chain: NB
Length: 479 amino acids
Theoretical weight: 54.65 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9NQZ2 (Residues: 1-479; Coverage: 100%)

Sequence domains:

U3 small nucleolar RNA-associated protein NOL7 Chain: ND

Molecule details ›

Chain: ND
Length: 257 amino acids
Theoretical weight: 29.48 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9UMY1 (Residues: 1-257; Coverage: 100%)

Sequence domains: NUC129 domain

Small ribosomal subunit protein uS15 Chain: NF

Molecule details ›

Chain: NF
Length: 151 amino acids
Theoretical weight: 17.26 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62277 (Residues: 1-151; Coverage: 100%)

Sequence domains:

Small ribosomal subunit protein uS11 Chain: NG

Molecule details ›

Chain: NG
Length: 151 amino acids
Theoretical weight: 16.3 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62263 (Residues: 1-151; Coverage: 100%)

Sequence domains: Ribosomal protein S11

Nucleolar protein 6 Chain: NH

Molecule details ›

Chain: NH
Length: 1146 amino acids
Theoretical weight: 127.75 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9H6R4 (Residues: 1-1146; Coverage: 100%)

Sequence domains:

Ribosomal RNA-processing protein 7 homolog A Chain: NI

Molecule details ›

Chain: NI
Length: 280 amino acids
Theoretical weight: 32.39 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y3A4 (Residues: 1-280; Coverage: 100%)

Sequence domains:

Dimethyladenosine transferase Chain: NL

Molecule details ›

Chain: NL
Length: 313 amino acids
Theoretical weight: 35.29 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9UNQ2 (Residues: 1-313; Coverage: 100%)

Sequence domains: Ribosomal RNA adenine dimethylase

Small ribosomal subunit protein eS1 Chain: NM

Molecule details ›

Chain: NM
Length: 264 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P61247 (Residues: 1-264; Coverage: 100%)

Sequence domains: Ribosomal S3Ae family

Small ribosomal subunit protein uS8 Chain: NO

Molecule details ›

Chain: NO
Length: 130 amino acids
Theoretical weight: 14.87 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62244 (Residues: 1-130; Coverage: 100%)

Sequence domains: Ribosomal protein S8

Small ribosomal subunit protein eS19 Chain: NP

Molecule details ›

Chain: NP
Length: 145 amino acids
Theoretical weight: 16.09 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P39019 (Residues: 1-145; Coverage: 100%)

Sequence domains: Ribosomal protein S19e

Small ribosomal subunit protein eS27 Chain: NQ

Molecule details ›

Chain: NQ
Length: 84 amino acids
Theoretical weight: 9.48 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P42677 (Residues: 1-84; Coverage: 100%)

Sequence domains: Ribosomal protein S27

RRP12-like protein Chain: NR

Molecule details ›

Chain: NR
Length: 861 amino acids
Theoretical weight: 73.29 KDa
Source organism: Homo sapiens

Probable ATP-dependent RNA helicase DHX37 Chain: NS

Molecule details ›

Chain: NS
Length: 1157 amino acids
Theoretical weight: 129.73 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q8IY37 (Residues: 1-1157; Coverage: 100%)

Sequence domains:

Ubiquitin-ribosomal protein eS31 fusion protein Chain: NT

Molecule details ›

Chain: NT
Length: 156 amino acids
Theoretical weight: 18 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62979 (Residues: 1-156; Coverage: 100%)

Sequence domains:

Small ribosomal subunit protein eS17 Chain: NU

Molecule details ›

Chain: NU
Length: 135 amino acids
Theoretical weight: 15.58 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P08708 (Residues: 1-135; Coverage: 100%)

Sequence domains: Ribosomal S17

Exosome complex component 10 Chain: NV

Molecule details ›

Chain: NV
Length: 885 amino acids
Theoretical weight: 100.97 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q01780 (Residues: 1-885; Coverage: 100%)

Sequence domains:

Nucleolar protein 56 Chain: SA

Molecule details ›

Chain: SA
Length: 594 amino acids
Theoretical weight: 66.16 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O00567 (Residues: 1-594; Coverage: 100%)

Sequence domains:

Nucleolar protein 58 Chain: SB

Molecule details ›

Chain: SB
Length: 529 amino acids
Theoretical weight: 59.69 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y2X3 (Residues: 1-529; Coverage: 100%)

Sequence domains:

rRNA 2'-O-methyltransferase fibrillarin Chains: SC, SD

Molecule details ›

Chains: SC, SD
Length: 321 amino acids
Theoretical weight: 33.84 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P22087 (Residues: 1-321; Coverage: 100%)

Sequence domains: Fibrillarin

NHP2-like protein 1 Chains: SE, SF

Molecule details ›

Chains: SE, SF
Length: 128 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P55769 (Residues: 1-128; Coverage: 100%)

Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

U3 small nucleolar RNA-interacting protein 2 Chain: SG

Molecule details ›

Chain: SG
Length: 475 amino acids
Theoretical weight: 51.92 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O43818 (Residues: 1-475; Coverage: 100%)

Sequence domains: WD domain, G-beta repeat

RNA 3'-terminal phosphate cyclase-like protein Chain: SH

Molecule details ›

Chain: SH
Length: 373 amino acids
Theoretical weight: 40.89 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y2P8 (Residues: 1-373; Coverage: 100%)

Sequence domains:

Ribosome biogenesis protein BMS1 homolog Chain: SI

Molecule details ›

Chain: SI
Length: 1282 amino acids
Theoretical weight: 146.04 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q14692 (Residues: 1-1282; Coverage: 100%)

Sequence domains:

Ribosomal RNA small subunit methyltransferase NEP1 Chains: SJ, SK

Molecule details ›

Chains: SJ, SK
Length: 244 amino acids
Theoretical weight: 26.76 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q92979 (Residues: 1-244; Coverage: 100%)

Sequence domains: EMG1/NEP1 methyltransferase

rRNA-processing protein FCF1 homolog Chain: SL

Molecule details ›

Chain: SL
Length: 198 amino acids
Theoretical weight: 23.42 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y324 (Residues: 1-198; Coverage: 100%)

Sequence domains: Fcf1

U3 small nucleolar ribonucleoprotein protein IMP4 Chain: SM

Molecule details ›

Chain: SM
Length: 291 amino acids
Theoretical weight: 33.82 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q96G21 (Residues: 1-291; Coverage: 100%)

Sequence domains: Brix domain

Small subunit processome component 20 homolog Chain: SP

Molecule details ›

Chain: SP
Length: 2785 amino acids
Theoretical weight: 318.81 KDa
Source organism: Homo sapiens
UniProt:

Canonical: O75691 (Residues: 1-2785; Coverage: 100%)

Sequence domains:

Deoxynucleotidyltransferase terminal-interacting protein 2 Chain: SQ

Molecule details ›

Chain: SQ
Length: 756 amino acids
Theoretical weight: 84.6 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q5QJE6 (Residues: 1-756; Coverage: 100%)

Sequence domains: Fcf2 pre-rRNA processing

Small ribosomal subunit protein uS12 Chain: SR

Molecule details ›

Chain: SR
Length: 143 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:

Canonical: P62266 (Residues: 1-143; Coverage: 100%)

Sequence domains: Ribosomal protein S12/S23

U3 small nucleolar RNA-associated protein 14 homolog A Chain: SS

Molecule details ›

Chain: SS
Length: 771 amino acids
Theoretical weight: 88.13 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9BVJ6 (Residues: 1-771; Coverage: 100%)

Sequence domains: Utp14 protein

Nucleolar protein 14 Chain: ST

Molecule details ›

Chain: ST
Length: 632 amino acids
Theoretical weight: 68.26 KDa
Source organism: Homo sapiens

Nucleolar complex protein 4 homolog Chain: SU

Molecule details ›

Chain: SU
Length: 472 amino acids
Theoretical weight: 50.18 KDa
Source organism: Homo sapiens

RNA-binding protein PNO1 Chain: SW

Molecule details ›

Chain: SW
Length: 252 amino acids
Theoretical weight: 27.97 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9NRX1 (Residues: 1-252; Coverage: 100%)

Sequence domains: Eukaryotic type KH-domain (KH-domain type I) (327.11.2)

Unassigned peptides Chain: SX

Molecule details ›

Chain: SX
Length: 228 amino acids
Theoretical weight: 19.42 KDa
Source organism: Homo sapiens

Probable U3 small nucleolar RNA-associated protein 11 Chain: SY

Molecule details ›

Chain: SY
Length: 253 amino acids
Theoretical weight: 30.52 KDa
Source organism: Homo sapiens
UniProt:

Canonical: Q9Y3A2 (Residues: 1-253; Coverage: 100%)

Sequence domains: Utp11 protein

Bystin Chain: SZ

Molecule details ›

Chain: SZ
Length: 304 amino acids
Theoretical weight: 33.71 KDa
Source organism: Homo sapiens

5'ETS rRNA Chain: L0

Molecule details ›

Chain: L0
Length: 3617 nucleotides
Theoretical weight: 1166.88 KDa
Source organism: Homo sapiens
Sequence domains: mir-663 microRNA precursor family

18S Ribosomal RNA Chain: L1

Molecule details ›

Chain: L1
Length: 1872 nucleotides
Theoretical weight: 604.23 KDa
Source organism: Homo sapiens
Sequence domains: Eukaryotic small subunit ribosomal RNA

U3 snoRNA Chain: L2

Molecule details ›

Chain: L2
Length: 217 nucleotides
Theoretical weight: 70.02 KDa
Source organism: Homo sapiens
Sequence domains: Small nucleolar RNA U3