Function and Biology Details
Reaction catalysed:
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WD40 repeat
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Protein arginine N-methyltransferase
- WD40 repeat, conserved site
- WD40-repeat-containing domain superfamily
- WD40/YVTN repeat-like-containing domain superfamily
- PRMT5, oligomerisation domain
- PRMT5 arginine-N-methyltransferase
2 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127081 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein arginine N-methyltransferase 5
Molecule details ›
Methylosome protein WDR77
Molecule details ›
Chain: B
Length: 366 amino acids
Theoretical weight: 39.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 366 amino acids
Theoretical weight: 39.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q9BQA1 (Residues: 2-342; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
