› 7nl7

X-ray diffraction
2.1Å resolution

Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand

Released:
DOI: 10.2210/pdb7nl7/pdb
PDB entry 7nl7 coloured by chain, front view.
PDB entry 7nl7 coloured by chain, side view.
PDB entry 7nl7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.
Cramer J, Lakkaichi A, Aliu B, Jakob RP, Klein S, Cattaneo I, Jiang X, Rabbani S, Schwardt O, Zimmer G, Ciancaglini M, Abreu Mota T, Maier T, Ernst B
J Am Chem Soc 143 17465-17478 (2021)
PMID: 34652144

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576170 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD209 antigen Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 18.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NNX6 (Residues: 250-404; Coverage: 38%)
Gene names: CD209, CLEC4L
Sequence domains: Lectin C-type domain

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand UH5 1 x UH5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P321
Unit cell:
a: 59.346Å b: 59.346Å c: 75.18Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.193 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection.
Pinho et al. (2023)
4 more

1 mention without citation

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)