7o1u

X-ray diffraction
1.7Å resolution

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 1 (BEV241)

Released:
Source organism: Homo sapiens
Primary publication:
OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
OpenAccess logo ACS Chem Biol 16 1692-1700 (2021)
PMID: 34415722

Function and Biology Details

Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Furin Chain: A
Molecule details ›
Chain: A
Length: 480 amino acids
Theoretical weight: 52.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09958 (Residues: 108-574; Coverage: 61%)
Gene names: FUR, FURIN, PACE, PCSK3
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P6522
Unit cell:
a: 131.714Å b: 131.714Å c: 155.727Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.156 0.155 0.167
Expression system: Homo sapiens