7ozf

X-ray diffraction
1.82Å resolution

FGFR1 kinase domain (residues 458-765) with mutations C488A, C584S in complex with 19.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-145801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 309 amino acids
Theoretical weight: 35.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11362 (Residues: 458-765; Coverage: 39%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 208.32Å b: 57.77Å c: 65.94Å
α: 90° β: 107.17° γ: 90°
R-values:
R R work R free
0.206 0.204 0.242
Expression system: Escherichia coli