› 7p4n

Solution NMR

NMR solution structure of the C6 domain of von Willebrand Factor

Released:
DOI: 10.2210/pdb7p4n/pdb
PDB entry 7p4n coloured by chain, ensemble of 20 models, front view.
PDB entry 7p4n coloured by chain, ensemble of 20 models, side view.
PDB entry 7p4n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the von Willebrand Factor C6 domain.
Chen PC, Kutzki F, Mojzisch A, Simon B, Xu ER, Aponte-Santamaría C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm MA, Gräter F, Hennig J
J Struct Biol 214 107923 (2022)
PMID: 36410652

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 8.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P04275 (Residues: 2647-2720; Coverage: 3%)
Gene names: F8VWF, VWF

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

1 review citation

Molecular mechanisms of catch bonds and their implications for platelet hemostasis.
Belyaev et al. (2023)
1 other article

1 mention without citation

Investigating the Pharmacological Mechanisms of Total Flavonoids from Eucommia ulmoides Oliver Leaves for Ischemic Stroke Protection.
Qin et al. (2024)