› 7p54

Electron Microscopy
3.3Å resolution

Cryo-EM structure of human TTYH2 in GDN

Released:
DOI: 10.2210/pdb7p54/pdb
PDB entry 7p54 coloured by chain, front view.
PDB entry 7p54 coloured by chain, side view.
PDB entry 7p54 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Sukalskaia A, Straub MS, Deneka D, Sawicka M, Dutzler R
OpenAccess logo Nat Commun 12 4893 (2021)
PMID: 34385445
Related structures: EMD-13194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protein tweety homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 541 amino acids
Theoretical weight: 59.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA4 (Residues: 2-534; Coverage: 100%)
Gene names: C17orf29, TTYH2
Sequence domains: Tweety

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-13194
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification.
Okada Y. (2024)
2 more

2 mentions without citation

Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
Sukalskaia et al. (2021)
1 more