› 7pnq

Electron Microscopy
3.7Å resolution

Human coronavirus OC43 spike glycoprotein ectodomain in complex with the 43E6 antibody Fab fragment

Released:
DOI: 10.2210/pdb7pnq/pdb
PDB entry 7pnq coloured by chain, front view.
PDB entry 7pnq coloured by chain, side view.
PDB entry 7pnq coloured by chain, top view.
Source organisms:
Primary publication:
Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes.
Wang C, Hesketh EL, Shamorkina TM, Li W, Franken PJ, Drabek D, van Haperen R, Townend S, van Kuppeveld FJM, Grosveld F, Ranson NA, Snijder J, de Groot RJ, Hurdiss DL, Bosch BJ
OpenAccess logo Nat Commun 13 2921 (2022)
PMID: 35614127
Related structures: EMD-13550

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225616 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
43E6 antibody heavy chain Chains: D, H, X
Molecule details ›
Chains: D, H, X
Length: 124 amino acids
Theoretical weight: 13.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
43E6 antibody light chain Chains: F, L, Y
Molecule details ›
Chains: F, L, Y
Length: 107 amino acids
Theoretical weight: 11.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1322 amino acids
Theoretical weight: 146.44 KDa
Source organism: Human coronavirus OC43
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 15 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-13550
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Antivirals for Broader Coverage against Human Coronaviruses.
Outteridge et al. (2024)
7 other articles

1 mention without citation

Human coronavirus OC43 nanobody neutralizes virus and protects mice from infection.
Adair et al. (2024)