› 7prl

X-ray diffraction
2.48Å resolution

MUC2 D1 with Cu(II)

Released:
DOI: 10.2210/pdb7prl/pdb
PDB entry 7prl coloured by chain, front view.
PDB entry 7prl coloured by chain, side view.
PDB entry 7prl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Intestinal mucin is a chaperone of multivalent copper.
Reznik N, Gallo AD, Rush KW, Javitt G, Fridmann-Sirkis Y, Ilani T, Nairner NA, Fishilevich S, Gokhman D, Chacón KN, Franz KJ, Fass D
Cell (2022)
PMID: 36206754

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-554292 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucin-2 Chain: A
Molecule details ›
Chain: A
Length: 395 amino acids
Theoretical weight: 43.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02817 (Residues: 1-389; Coverage: 7%)
Gene names: MUC2, SMUC
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand GOL 4 x GOL
Ligand CU 1 x CU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2221
Unit cell:
a: 95.9Å b: 141.21Å c: 68.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.186 0.26
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Cuproptosis: unveiling a new frontier in cancer biology and therapeutics.
Feng et al. (2024)
2 more

1 mention without citation

VWD domain stabilization by autocatalytic Asp-Pro cleavage.
Yeshaya et al. (2024)