› 7rnv

X-ray diffraction
2.15Å resolution

SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with phosphorylated tyrosine 53

Released:
DOI: 10.2210/pdb7rnv/pdb
PDB entry 7rnv coloured by chain, front view.
PDB entry 7rnv coloured by chain, side view.
PDB entry 7rnv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dai S, Horton JR, Cheng X

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-279964 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Guanine nucleotide exchange factor VAV2 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52735 (Residues: 665-774; Coverage: 13%)
Gene name: VAV2
Sequence domains: SH2 domain
Actin, alpha skeletal muscle Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68133 (Residues: 52-60; Coverage: 2%)
Gene names: ACTA, ACTA1

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-003
Spacegroup: C222
Unit cell:
a: 61.492Å b: 109.432Å c: 41.867Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.23 0.272
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links