› 7s61

Electron Microscopy
4Å resolution

Human KATP channel in open conformation, focused on Kir and one SUR, position 5

Released:
DOI: 10.2210/pdb7s61/pdb
PDB entry 7s61 coloured by chain, front view.
PDB entry 7s61 coloured by chain, side view.
PDB entry 7s61 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular structure of an open human KATP channel.
Zhao C, MacKinnon R
Proc Natl Acad Sci U S A 118 (2021)
PMID: 34815345
Related structures: EMD-24846

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170790 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-sensitive inward rectifier potassium channel 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 390 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14654 (Residues: 1-390; Coverage: 100%)
Gene name: KCNJ11
Sequence domains:
ATP-binding cassette sub-family C member 8 Chain: E
Molecule details ›
Chain: E
Length: 1582 amino acids
Theoretical weight: 177.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q09428 (Residues: 2-1581; Coverage: 100%)
  • Best match: Q09428-2 (Residues: 2-1582)
Gene names: ABCC8, HRINS, SUR, SUR1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 2 x MG
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-24846
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Potassium Channels as a Target for Cancer Therapy: Current Perspectives.
Zúñiga et al. (2022)
10 more

1 mention without citation

Ligand-mediated Structural Dynamics of a Mammalian Pancreatic KATP Channel.
Sung et al. (2022)