› 7sbd

X-ray diffraction
3.04Å resolution

Murine Fab/IgE in complex with profilin from Hevea brasieliensis (Hev b 8)

Released:
DOI: 10.2210/pdb7sbd/pdb
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PDB entry 7sbd coloured by chain, front view.
PDB entry 7sbd coloured by chain, side view.
PDB entry 7sbd coloured by chain, top view.
Source organisms:
Primary publication:
A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity.
García-Ramírez B, Mares-Mejía I, Rodríguez-Hernández A, Cano-Sánchez P, Torres-Larios A, Ortega E, Rodríguez-Romero A
OpenAccess logo Commun Biol 5 748 (2022)
PMID: 35902770

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226377 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Fab/IgE Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 209 amino acids
Theoretical weight: 23.23 KDa
Source organism: Mus musculus
Fab/IgE Light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.62 KDa
Source organism: Mus musculus
Profilin-2 Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: P212121
Unit cell:
a: 57.962Å b: 77.468Å c: 144.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.254
Expression system: Escherichia coli

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Citations

2 review citations

Precision engineering for localization, validation, and modification of allergenic epitopes.
Pomés et al. (2024)
1 more

3 mentions without citation

Human Monoclonal IgE Antibodies-a Major Milestone in Allergy.
Smith et al. (2023)
2 more

PDB-REDO

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