Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- FATC domain
- Phosphatidylinositol 3/4-kinase, conserved site
- Telomere-length maintenance and DNA damage repair
- Nibrin, C-terminal
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- ATM, catalytic domain
- Protein kinase-like domain superfamily
4 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Serine-protein kinase ATM and Nibrin (preferred)
PDBe Complex ID:
PDB-CPX-521288 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine-protein kinase ATM
Molecule details ›
Chains: A, C
Length: 3056 amino acids
Theoretical weight: 351.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 3056 amino acids
Theoretical weight: 351.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q13315 (Residues: 1-3056; Coverage: 100%)
Sequence domains:
Nibrin
Molecule details ›
Chains: B, D
Length: 28 amino acids
Theoretical weight: 3.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: DNA damage repair protein Nbs1
Length: 28 amino acids
Theoretical weight: 3.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: O60934 (Residues: 727-754; Coverage: 4%)
Sequence domains: DNA damage repair protein Nbs1
