› 7sob

Electron Microscopy
2.4Å resolution

SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement

Released:
DOI: 10.2210/pdb7sob/pdb
PDB entry 7sob coloured by chain, front view.
PDB entry 7sob coloured by chain, side view.
PDB entry 7sob coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants.
McCallum M, Walls AC, Sprouse KR, Bowen JE, Rosen LE, Dang HV, De Marco A, Franko N, Tilles SW, Logue J, Miranda MC, Ahlrichs M, Carter L, Snell G, Pizzuto MS, Chu HY, Van Voorhis WC, Corti D, Veesler D
Science 374 1621-1626 (2021)
PMID: 34751595
Related structures: EMD-25265

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210306 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein Chains: A, D, K
Molecule details ›
Chains: A, D, K
Length: 1277 amino acids
Theoretical weight: 141.87 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
S2L20 Fab light chain Chains: B, E, L
Molecule details ›
Chains: B, E, L
Length: 107 amino acids
Theoretical weight: 11.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S2L20 Fab heavy chain Chains: C, F, M
Molecule details ›
Chains: C, F, M
Length: 121 amino acids
Theoretical weight: 13.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S309 Fab heavy chain Chains: G, H, N
Molecule details ›
Chains: G, H, N
Length: 128 amino acids
Theoretical weight: 14.04 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S309 Fab light chain Chains: I, J, O
Molecule details ›
Chains: I, J, O
Length: 100 amino acids
Theoretical weight: 10.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 51 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.4Å
Relevant EMDB volumes: EMD-25265
Expression system: Homo sapiens

Quick links

Citations

21 review citations

The Evolution and Biology of SARS-CoV-2 Variants.
Telenti et al. (2022)
20 more

4 mentions without citation

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants.
Chi et al. (2023)
3 more