PDB 7sx4 structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

protein binding

Biological process:

monoatomic cation transmembrane transport

Cellular component:

plasma membrane

Sequence domains:

6 more domains

Structure analysis Details

Assembly composition:

hetero pentamer (preferred)

Assembly name:

NALCN channelosome complex and Calmodulin-1 (preferred)

PDBe Complex ID:

PDB-CPX-502096 (preferred)

Entry contents:

5 distinct polypeptide molecules

Macromolecules (5 distinct):

Sodium leak channel NALCN Chain: A

Molecule details ›

Chain: A
Length: 2042 amino acids
Theoretical weight: 234.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: Q8IZF0 (Residues: 1-1738; Coverage: 100%)

Gene names: NALCN, VGCNL1
Sequence domains: Ion transport protein

NALCN channel auxiliary factor 1 Chain: B

Molecule details ›

Chain: B
Length: 483 amino acids
Theoretical weight: 54.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: B1AL88 (Residues: 1-458; Coverage: 100%)

Gene names: FAM155A, NALF1, NLF-1

Calmodulin-1 Chain: C

Molecule details ›

Chain: C
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)

Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Protein unc-79 homolog Chain: D

Molecule details ›

Chain: D
Length: 2561 amino acids
Theoretical weight: 285.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: Q9P2D8 (Residues: 173-2635; Coverage: 94%)

Gene names: KIAA1409, UNC79
Sequence domains: Cation-channel complex subunit UNC-79

Protein unc-80 homolog Chain: E

Molecule details ›

Chain: E
Length: 3283 amino acids
Theoretical weight: 366.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt: