› 7t36

X-ray diffraction
1.65Å resolution

Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322

Released:
DOI: 10.2210/pdb7t36/pdb
PDB entry 7t36 coloured by chain, front view.
PDB entry 7t36 coloured by chain, side view.
PDB entry 7t36 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Karim MR, Schonbrunn E

Function and Biology Details

Reactions catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-539869 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription initiation factor TFIID subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 30.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21675 (Residues: 1394-1656; Coverage: 14%)
Gene names: BA2R, CCG1, CCGS, TAF1, TAF2A
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand EIO 1 x EIO
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 45.3Å b: 54.299Å c: 122.709Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.203
Expression system: Escherichia coli

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