› 7u9u

X-ray diffraction
1.66Å resolution

Function and Biology Details

Reaction catalysed: 
A D-amino acid + H(2)O + O(2) = a 2-oxo carboxylate + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147153 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-amino-acid oxidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 347 amino acids
Theoretical weight: 39.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14920 (Residues: 1-347; Coverage: 100%)
Gene names: DAMOX, DAO
Sequence domains: FAD dependent oxidoreductase

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
2 bound ligands:
Ligand BEZ 1 x BEZ
Ligand M89 1 x M89
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21212
Unit cell:
a: 122.806Å b: 73.403Å c: 79.799Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.235
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics.
de Bartolomeis et al. (2022)
2 more