› 7uai

Electron Microscopy
2.8Å resolution

Meprin alpha helix in complex with fetuin-B

Released:
DOI: 10.2210/pdb7uai/pdb
PDB entry 7uai coloured by chain, front view.
PDB entry 7uai coloured by chain, side view.
PDB entry 7uai coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor.
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jäger C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
OpenAccess logo Nat Commun 13 6178 (2022)
PMID: 36261433
Related structures: EMD-26426

Function and Biology Details

Reaction catalysed: 
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172583 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Meprin A subunit alpha Chains: B, C, D, E
Molecule details ›
Chains: B, C, D, E
Length: 587 amino acids
Theoretical weight: 67.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q16819 (Residues: 22-600; Coverage: 80%)
Gene name: MEP1A
Sequence domains:
Fetuin-B Chains: A, H
Molecule details ›
Chains: A, H
Length: 388 amino acids
Theoretical weight: 42.93 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UGM5 (Residues: 1-382; Coverage: 100%)
Gene name: FETUB
Sequence domains: Cystatin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
3 bound ligands:
Ligand CA 8 x CA
Ligand ZN 4 x ZN
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-26426
Expression systems:
  • Drosophila melanogaster
  • Homo sapiens

Quick links

Citations

4 citation in other articles

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Chenavier et al. (2023)
3 more

1 mention without citation

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Danneskiold-Samsøe et al. (2023)