› 7ur4

Electron Microscopy
3.34Å resolution

Cryo-EM Structure of the Neutralizing Antibody MPV467 in Complex with Prefusion Human Metapneumovirus F Glycoprotein

Released:
DOI: 10.2210/pdb7ur4/pdb
PDB entry 7ur4 coloured by chain, front view.
PDB entry 7ur4 coloured by chain, side view.
PDB entry 7ur4 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus.
Banerjee A, Huang J, Rush SA, Murray J, Gingerich AD, Royer F, Hsieh CL, Tripp RA, McLellan JS, Mousa JJ
OpenAccess logo Proc Natl Acad Sci U S A 119 e2203326119 (2022)
PMID: 35696580
Related structures: EMD-26704

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212418 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 551 amino acids
Theoretical weight: 60.49 KDa
Source organism: human metapneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6WB98 (Residues: 1-490; Coverage: 91%)
Gene name: F
Sequence domains: Fusion glycoprotein F0
MPV467 Fab Heavy chain Chains: F, H, I
Molecule details ›
Chains: F, H, I
Length: 223 amino acids
Theoretical weight: 24.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
MPV467 Fab Light chain Chains: G, J, L
Molecule details ›
Chains: G, J, L
Length: 211 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.34Å
Relevant EMDB volumes: EMD-26704
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Structural basis for respiratory syncytial virus and human metapneumovirus neutralization.
Miller et al. (2023)
6 other articles