› 7v6z

Electron Microscopy
3.64Å resolution

Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom (reprocessed with the dataset of 7dzp)

Released:
DOI: 10.2210/pdb7v6z/pdb
PDB entry 7v6z coloured by chain, front view.
PDB entry 7v6z coloured by chain, side view.
PDB entry 7v6z coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
Luo Y, Wan G, Zhang X, Zhou X, Wang Q, Fan J, Cai H, Ma L, Wu H, Qu Q, Cong Y, Zhao Y, Li D
Structure 29 1286-1294.e6 (2021)
PMID: 34174188
Related structures: EMD-31754

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178858 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protein patched homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 1090 amino acids
Theoretical weight: 121.61 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q61115 (Residues: 2-1175; Coverage: 75%)
Gene names: Ptch, Ptch1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 3 x NAG
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.64Å
Relevant EMDB volumes: EMD-31754
Expression system: Homo sapiens

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Citations

1 review citation

The lipid rafts in cancer stem cell: a target to eradicate cancer.
Zhang et al. (2022)
3 other articles