› 7wf3

Electron Microscopy
3.4Å resolution

Composite map of human Kv1.3 channel in apo state with beta subunits

Released:
DOI: 10.2210/pdb7wf3/pdb
PDB entry 7wf3 coloured by chain, front view.
PDB entry 7wf3 coloured by chain, side view.
PDB entry 7wf3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.
Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG, Bhushan S
OpenAccess logo Proc Natl Acad Sci U S A 119 (2022)
PMID: 35091471
Related structures: EMD-32459

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-540012 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Potassium voltage-gated channel subfamily A member 3 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 286 amino acids
Theoretical weight: 31.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22001 (Residues: 208-493; Coverage: 50%)
Gene names: HGK5, KCNA3
Sequence domains:
Voltage-gated potassium channel subunit beta-2 Chains: C, G, I, M
Molecule details ›
Chains: C, G, I, M
Length: 328 amino acids
Theoretical weight: 36.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13303 (Residues: 34-361; Coverage: 89%)
Gene names: KCNA2B, KCNAB2, KCNK2
Sequence domains: Aldo/keto reductase family
Potassium voltage-gated channel subfamily A member 3 Chains: J, N, O, P
Molecule details ›
Chains: J, N, O, P
Length: 106 amino acids
Theoretical weight: 12.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22001 (Residues: 99-204; Coverage: 18%)
Gene names: HGK5, KCNA3
Sequence domains: BTB/POZ domain

Ligands and Environments

2 bound ligands:
Ligand K 4 x K
Ligand NAP 4 x NAP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-32459
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Potassium Channels as a Target for Cancer Therapy: Current Perspectives.
Zúñiga et al. (2022)
3 more

3 mentions without citation

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads.
Chandy et al. (2023)
2 more