› 7wfr

Electron Microscopy
3Å resolution

Human Nav1.8 with A-803467, class III

Released:
DOI: 10.2210/pdb7wfr/pdb
PDB entry 7wfr coloured by chain, front view.
PDB entry 7wfr coloured by chain, side view.
PDB entry 7wfr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8.
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
OpenAccess logo Proc Natl Acad Sci U S A 119 e2208211119 (2022)
PMID: 35858452
Related structures: EMD-32475

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195304 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Sodium channel protein type 10 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1956 amino acids
Theoretical weight: 220.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5Y9 (Residues: 1-1956; Coverage: 100%)
Gene name: SCN10A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
6 bound ligands:
Ligand NAG 3 x NAG
Ligand 95T 1 x 95T
Ligand CLR 5 x CLR
Ligand PCW 7 x PCW
Ligand LPE 12 x LPE
Ligand P5S 1 x P5S
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-32475
Expression system: Homo sapiens

Quick links

Citations

16 citation in other articles

Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1.7.
Huang et al. (2022)
15 more

1 mention without citation

A structural atlas of druggable sites on Nav channels.
Li et al. (2024)