› 7wl4

X-ray diffraction
1.82Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50

Released:
DOI: 10.2210/pdb7wl4/pdb
PDB entry 7wl4 coloured by chain, front view.
PDB entry 7wl4 coloured by chain, side view.
PDB entry 7wl4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors.
Li W, Zhang C, Zhang HE, Dong R, Liu JY, Wang CM, Wang M, Wang YW, Wang C, Zhang Y, Shi L, Xu Y, Sun LP
Bioorg Chem 127 105917 (2022)
PMID: 35738217

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 141 amino acids
Theoretical weight: 16.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand JFU 4 x JFU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P21
Unit cell:
a: 59.858Å b: 42.484Å c: 107.309Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.221
Expression system: Escherichia coli

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