› 7wz5

X-ray diffraction
1.39Å resolution

Larimichthys crocea IFNi

Released:
DOI: 10.2210/pdb7wz5/pdb
PDB entry 7wz5 coloured by chain, front view.
PDB entry 7wz5 coloured by chain, side view.
PDB entry 7wz5 coloured by chain, top view.
Source organism: Larimichthys crocea
Primary publication:
Molecular and Structural Basis of Receptor Binding and Signaling of a Fish Type I IFN with Three Disulfide Bonds.
Chen J, Guan Y, Guan H, Mu Y, Ding Y, Zou J, Ouyang S, Chen X
J Immunol 209 806-819 (2022)
PMID: 35906001

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104874 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon C Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 17.98 KDa
Source organism: Larimichthys crocea
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: A0A3G3BTG1 (Residues: 26-186; Coverage: 98%)
Gene name: D5F01_LYC18041
Sequence domains: Interferon alpha/beta domain

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 36.31Å b: 60.62Å c: 81.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.199 0.213
Expression system: Baculovirus expression vector pFastBac1-HM

Quick links

Citations

3 citation in other articles

Large yellow croaker (Larimichthys crocea) mitofusin 2 inhibits type I IFN responses by degrading MAVS via enhanced K48-linked ubiquitination.
Li et al. (2023)
2 more

1 mention without citation

Structural and Functional Characterization of a Fish Type I Subgroup d IFN Reveals Its Binding to Receptors.
Guan et al. (2024)