› 7xvw

X-ray diffraction
1.94Å resolution

Structure of neuraminidase from influenza B-like viruses derived from spiny eel

Released:
DOI: 10.2210/pdb7xvw/pdb
PDB entry 7xvw coloured by chain, front view.
PDB entry 7xvw coloured by chain, side view.
PDB entry 7xvw coloured by chain, top view.
Source organism: Wuhan spiny eel influenza virus
Primary publication:
Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel.
Li L, Chai Y, Peng W, Li D, Sun L, Gao GF, Qi J, Xiao H, Liu WJ, von Itzstein M, Gao F
Proc Natl Acad Sci U S A 119 e2210724119 (2022)
PMID: 36191180

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104386 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 404 amino acids
Theoretical weight: 43.85 KDa
Source organism: Wuhan spiny eel influenza virus
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: A0A2P1GNP4 (Residues: 83-472; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase

Ligands and Environments

3 bound ligands:
Ligand BCZ 2 x BCZ
Ligand NAG 2 x NAG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: I4
Unit cell:
a: 126.085Å b: 126.085Å c: 110.432Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.157 0.19
Expression system: Baculovirus expression vector pFastBac1-HM

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