› 7z0x

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272824 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
THSC20.HVTR26 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 237 amino acids
Theoretical weight: 24.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
THSC20.HVTR26 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chain: R
Molecule details ›
Chain: R
Length: 205 amino acids
Theoretical weight: 23.02 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 331-527; Coverage: 16%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
1 bound ligand:
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21212
Unit cell:
a: 90.286Å b: 104.213Å c: 89.064Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.162 0.188
Expression system: Homo sapiens

Quick links

Citations

6 citation in other articles

Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions.
Rizvi et al. (2023)
5 more

2 mentions without citation

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant.
Hingankar et al. (2022)
1 more