› 7zc9

X-ray diffraction
2.1Å resolution

Human Pikachurin/EGFLAM C-terminal Laminin-G domain (LG3)

Released:
DOI: 10.2210/pdb7zc9/pdb
PDB entry 7zc9 coloured by chain, front view.
PDB entry 7zc9 coloured by chain, side view.
PDB entry 7zc9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR, Singh AK, Forneris F, Martemyanov KA
Sci Signal 16 eadd9539 (2023)
PMID: 37490546

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pikachurin Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q63HQ2 (Residues: 820-1009; Coverage: 19%)
  • Best match: Q63HQ2-5 (Residues: 1-144)
Gene names: AGRINL, AGRNL, EGFLAM, PIKA
Sequence domains: Laminin G domain

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand SO4 18 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2221
Unit cell:
a: 73.805Å b: 103.818Å c: 133.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.246
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing.
Yun et al. (2024)

1 mention without citation

Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Patil et al. (2023)