› 7a34

X-ray diffraction
1.85Å resolution

Intertwined dimer of the c-Src SH3 domain mutant V111L-N113S-T114S

Released:
DOI: 10.2210/pdb7a34/pdb
Model geometry
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PDB entry 7a34 coloured by chain, front view.
PDB entry 7a34 coloured by chain, side view.
PDB entry 7a34 coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Camara-Artigas A, Plaza-Garrido M, Salinas-Garcia MC

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.72 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 82-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain

Ligands and Environments

2 bound ligands:
Ligand PGE 1 x PGE
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P6522
Unit cell:
a: 47.242Å b: 47.242Å c: 125.167Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.2 0.227
Expression system: Escherichia coli BL21(DE3)

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