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Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer)

Source organisms:
Biochemical function: not assigned
Biological process: endocytosis involved in viral entry into host cell
Cellular component: virion membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01601
Domain description: Coronavirus spike glycoprotein S2
Occurring in:
  1. Fibritin; Spike glycoprotein
The deposited structure of PDB entry 7a4n contains 3 copies of Pfam domain PF01601 ( Coronavirus spike glycoprotein S2) in Fibritin. Showing 1 copy in chain A.

PF19209
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Fibritin; Spike glycoprotein
The deposited structure of PDB entry 7a4n contains 3 copies of Pfam domain PF19209 ( Coronavirus spike glycoprotein S1, C-terminal) in Fibritin. Showing 1 copy in chain A.

PF09408
Domain description: Betacoronavirus spike glycoprotein S1, receptor binding
Occurring in:
  1. Fibritin; Spike glycoprotein
The deposited structure of PDB entry 7a4n contains 3 copies of Pfam domain PF09408 ( Betacoronavirus spike glycoprotein S1, receptor binding) in Fibritin. Showing 1 copy in chain A.

PF16451
Domain description: Betacoronavirus-like spike glycoprotein S1, N-terminal
Occurring in:
  1. Fibritin; Spike glycoprotein
The deposited structure of PDB entry 7a4n contains 3 copies of Pfam domain PF16451 ( Betacoronavirus-like spike glycoprotein S1, N-terminal) in Fibritin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR043473
Domain description: Spike glycoprotein S2 superfamily, coronavirus
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR018548
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR032500
Domain description: Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR012473
Domain description: Fibritin C-terminal
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR044874
Domain description: Spike glycoprotein S2, coronavirus, heptad repeat 2
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR044873
Domain description: Spike glycoprotein S2, coronavirus, heptad repeat 1
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR002552
Domain description: Spike glycoprotein S2, coronavirus
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR043607
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR036326
Domain description: Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR044366
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR043002
Domain description: Spike glycoprotein, N-terminal domain superfamily
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR044341
Domain description: Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like
Occurring in:
  1. Fibritin; Spike glycoprotein
IPR042578
Domain description: Spike glycoprotein, betacoronavirus
Occurring in:
  1. Fibritin; Spike glycoprotein

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