› 7a56

X-ray diffraction
1.85Å resolution

Schmallenberg Virus Envelope Glycoprotein Gc Fusion Domains in Postfusion Conformation

Released:
DOI: 10.2210/pdb7a56/pdb
PDB entry 7a56 coloured by chain, front view.
PDB entry 7a56 coloured by chain, side view.
PDB entry 7a56 coloured by chain, top view.
Source organism: Bovine Schmallenberg virus BH80/Germany/2011
Primary publication:
Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.
Hellert J, Aebischer A, Haouz A, Guardado-Calvo P, Reiche S, Beer M, Rey FA
Cell Rep 42 112142 (2023)
PMID: 36827185

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein C Chain: A
Molecule details ›
Chain: A
Length: 437 amino acids
Theoretical weight: 48.3 KDa
Source organism: Bovine Schmallenberg virus BH80/Germany/2011
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: H2AM12 (Residues: 881-1306; Coverage: 31%)
Gene name: GP
Sequence domains: Bunyavirus glycoprotein G1

Ligands and Environments

4 bound ligands:
Ligand CL 6 x CL
Ligand PO4 3 x PO4
Ligand NA 4 x NA
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: R32
Unit cell:
a: 86.79Å b: 86.79Å c: 358.09Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.17 0.208
Expression system: Drosophila melanogaster

Quick links

Citations

2 citation in other articles

Characterization of a monoclonal antibody specific to California serogroup orthobunyaviruses and development as a chimeric immunoglobulin M-positive control in human diagnostics.
Powers et al. (2023)
1 more

1 mention without citation

In Silico Physicochemical Characterization of Fusion Proteins from Emerging Amazonian Arboviruses.
Leal et al. (2023)