› 7a7h

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:
Ligand TK9 1 x TK9
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P41212
Unit cell:
a: 62.325Å b: 62.325Å c: 167.629Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.231 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension.
Imig JD. (2023)
1 other article