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Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.

Source organism: Homo sapiens
Biochemical function: sequence-specific DNA binding
Biological process: transcription initiation at mitochondrial promoter
Cellular component: mitochondrial nucleoid

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EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00940
Domain description: DNA-dependent RNA polymerase
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
The deposited structure of PDB entry 7a8p contains 1 copy of Pfam domain PF00940 (DNA-dependent RNA polymerase) in DNA-directed RNA polymerase, mitochondrial. Showing 1 copy in chain A.

PF14700
Domain description: DNA-directed RNA polymerase N-terminal
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
The deposited structure of PDB entry 7a8p contains 1 copy of Pfam domain PF14700 (DNA-directed RNA polymerase N-terminal) in DNA-directed RNA polymerase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002092
Domain description: DNA-directed RNA polymerase, phage-type
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
IPR029262
Domain description: DNA-directed RNA polymerase, N-terminal
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
IPR046950
Domain description: DNA-directed RNA polymerase, C-terminal domain, phage-type
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
IPR037159
Domain description: DNA-directed RNA polymerase, N-terminal domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase, mitochondrial

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