› 7a8y

X-ray diffraction
1.75Å resolution

X-ray crystal structure of Aspartate alpha-decarboxylase in complex with D-Serine

Released:
DOI: 10.2210/pdb7a8y/pdb
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PDB entry 7a8y coloured by chain, front view.
PDB entry 7a8y coloured by chain, side view.
PDB entry 7a8y coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Structure and diffusive dynamics of aspartate α-decarboxylase (ADC) liganded with D-serine in aqueous solution.
Raskar T, Niebling S, Devos JM, Yorke BA, Härtlein M, Huse N, Forsyth VT, Seydel T, Pearson AR
OpenAccess logo Phys Chem Chem Phys (2022)
PMID: 35980136

Function and Biology Details

Reaction catalysed: 
L-aspartate = beta-alanine + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105263 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aspartate 1-decarboxylase beta chain Chains: AAA, DDD
Molecule details ›
Chains: AAA, DDD
Length: 27 amino acids
Theoretical weight: 3.06 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A4Y8GT61 (Residues: 1-24; Coverage: 19%)
Gene names: FKO60_12525, panD
Aspartate 1-decarboxylase alpha chain Chains: BBB, EaE
Molecule details ›
Chains: BBB, EaE
Length: 94 amino acids
Theoretical weight: 10.22 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A4Y8GT61 (Residues: 25-118; Coverage: 75%)
Gene names: FKO60_12525, panD
Sequence domains: Aspartate decarboxylase

Ligands and Environments

3 bound ligands:
Ligand DSN 3 x DSN
Ligand EDO 1 x EDO
Ligand SER 1 x SER
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6122
Unit cell:
a: 71.3Å b: 71.3Å c: 216.65Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.17 0.19
Expression system: Escherichia coli

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Citations

2 citation in other articles

Cooperative Change in the Internal Dynamics of Streptavidin Caused by Biotin Binding.
Sarter M. (2023)
1 more

1 mention without citation

Structure and diffusive dynamics of aspartate α-decarboxylase (ADC) liganded with D-serine in aqueous solution.
Raskar et al. (2022)

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