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Truncated 1-deoxy-D-xylulose 5-phosphate synthase (DXS) from Mycobacterium tuberculosis

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological process: terpenoid biosynthetic process
Cellular component: not assigned

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EC 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase

Reaction catalysed:
Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO(2)
Systematic name:
Pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)
Alternative Name(s):
  • 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)
  • 1-deoxyxylulose-5-phosphate synthase
  • DXP-synthase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02780
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
The deposited structure of PDB entry 7a9h contains 2 copies of Pfam domain PF02780 (Transketolase, C-terminal domain) in 1-deoxy-D-xylulose-5-phosphate synthase. Showing 1 copy in chain B [auth BBB].

PF02779
Domain description: Transketolase, pyrimidine binding domain
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
The deposited structure of PDB entry 7a9h contains 2 copies of Pfam domain PF02779 (Transketolase, pyrimidine binding domain) in 1-deoxy-D-xylulose-5-phosphate synthase. Showing 1 copy in chain B [auth BBB].

PF13292
Domain description: 1-deoxy-D-xylulose-5-phosphate synthase
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
The deposited structure of PDB entry 7a9h contains 2 copies of Pfam domain PF13292 (1-deoxy-D-xylulose-5-phosphate synthase) in 1-deoxy-D-xylulose-5-phosphate synthase. Showing 1 copy in chain B [auth BBB].

InterPro InterPro annotations
IPR005477
Domain description: Deoxyxylulose-5-phosphate synthase
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
IPR009014
Domain description: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
IPR005475
Domain description: Transketolase-like, pyrimidine-binding domain
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
IPR033248
Domain description: Transketolase, C-terminal domain
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
IPR020826
Domain description: Transketolase binding site
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase
IPR005474
Domain description: Transketolase, N-terminal
Occurring in:
  1. 1-deoxy-D-xylulose-5-phosphate synthase

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